Karyotyping detects chromosomal abnormalities such as deletions, duplications, translocations, and aneuploidy. In toxicology, it is used to assess genotoxic potential, evaluate reproductive toxicity, and support impurity or metabolite safety assessments. While less sensitive than newer molecular methods, it remains a foundational cytogenetic technique.
Why It Matters in Toxicology / When It’s Used: Regulatory agencies consider chromosomal damage a major safety concern. Karyotyping is often included in the battery of genetic toxicology assessments.
Related Terms: Genotoxicity, Micronucleus Test, Ames Test, Chromosomal Aberration Test
Tags: #Genotoxicity #Cytogenetics #GeneticToxicology